The story starts in 1944 when Crinos Industria Farmacobiologica S.p.A.was founded in Como, Italy, with the aim of searching and developing prescription drugs, while it later engaged into the development of innovative cosmetic products. 

In the mid-1960s a research on arteriosclerosis, lead to the discovery of Tricosaccaride®, the first substance that stimulated hair growth. 

This discovery, in turn, lead to a series of studies that identified the main active ingredient for the treatment against hair loss. This active, was patented under the name Tricosaccaride® and is considered the cornerstone of the Foltène®PHARMA brand.